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DKA symptoms SGLT2 — GPhC CRA MCQ

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HardEndocrine TherapeuticsDKA symptoms SGLT2GPhC CRA

A patient taking empagliflozin reports abdominal pain, vomiting and breathlessness but their glucose is not very high. They ask for an antiemetic. What is the most appropriate action?

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Correct answer: E — Refer urgently for possible ketoacidosis

SGLT2 inhibitors can cause euglycaemic diabetic ketoacidosis. Vomiting, abdominal pain and breathlessness require urgent assessment even if glucose is not markedly raised. In this scenario, the correct option is refer urgently for possible ketoacidosis. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; MHRA Drug Safety Update