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Warfarin and amiodarone — GPhC CRA MCQ

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HardDrug InteractionsWarfarin and amiodaroneGPhC CRA

A patient stabilised on warfarin starts amiodarone after a cardiology appointment. They ask whether INR checks can stay monthly. What is the most important interaction to flag?

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Correct answer: D — Increased INR requiring closer monitoring

Amiodarone can increase warfarin effect and bleeding risk. INR monitoring should be intensified when amiodarone is started, stopped or changed. In this scenario, the correct option is increased INR requiring closer monitoring. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions