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Calcium and quinolone — GPhC CRA MCQ

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EasyDrug InteractionsCalcium and quinoloneGPhC CRA

A patient prescribed ciprofloxacin asks to take it with calcium tablets and milk because it upsets their stomach. What is the most important interaction to flag?

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Correct answer: C — Reduced ciprofloxacin absorption by chelation

Calcium can bind quinolones and reduce absorption. Separating administration times is important for treatment effectiveness. In this scenario, the correct option is reduced ciprofloxacin absorption by chelation. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions