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Antiplatelet bleeding safety — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsAntiplatelet bleeding safetyGPhC CRA

A patient taking aspirin and clopidogrel after ACS requests ibuprofen for back pain. They have a history of dyspepsia. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Increased gastrointestinal bleeding risk

NSAIDs increase gastrointestinal bleeding risk, particularly with dual antiplatelet therapy. The pharmacist should advise a safer analgesic approach and refer if needed. In this scenario, the correct option is increased gastrointestinal bleeding risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions