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Methotrexate weekly dosing — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A patient prescribed methotrexate 10 mg weekly says they took it daily for three days by mistake. They feel mouth soreness and nausea. What is the most appropriate action?

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Correct answer: C — Refer urgently for assessment of methotrexate toxicity

Daily methotrexate dosing errors can cause serious toxicity. Mouth ulcers and nausea after overdose require urgent medical assessment. In this scenario, the correct option is refer urgently for assessment of methotrexate toxicity. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment