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ACE inhibitor and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsACE inhibitor and NSAIDGPhC CRA

A patient taking ramipril and furosemide asks to buy naproxen for back pain after a long walk. They have CKD stage 3 on the PMR. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Acute kidney injury risk from ACE inhibitor, diuretic and NSAID

The combination of ACE inhibitor, diuretic and NSAID can reduce renal perfusion and precipitate acute kidney injury. CKD makes the interaction more clinically significant. In this scenario, the correct option is acute kidney injury risk from ACE inhibitor, diuretic and NSAID. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions