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MAOI interaction — GPhC CRA MCQ

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HardCNS TherapeuticsMAOI interactionGPhC CRA

A patient taking phenelzine asks to buy pseudoephedrine for nasal congestion. Their blood pressure is usually well controlled. What is the most important interaction to flag?

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Correct answer: B — Hypertensive crisis risk from sympathomimetic interaction

MAOIs interact dangerously with sympathomimetics such as pseudoephedrine. The sale should be avoided and safer options considered. In this scenario, the correct option is hypertensive crisis risk from sympathomimetic interaction. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions