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Sildenafil and alpha-blocker — GPhC CRA MCQ

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ModerateDrug InteractionsSildenafil and alpha-blockerGPhC CRA

A patient taking doxazosin for BPH asks to buy sildenafil. They report dizziness when standing in the morning. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Postural hypotension risk from additive vasodilation

Sildenafil and alpha-blockers can have additive blood pressure lowering effects. Existing postural symptoms require caution and referral or medical review. In this scenario, the correct option is postural hypotension risk from additive vasodilation. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; MEP