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Diltiazem and DOAC — GPhC CRA MCQ

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ModerateDrug InteractionsDiltiazem and DOACGPhC CRA

A patient taking diltiazem is newly prescribed apixaban. They are elderly and have borderline renal function. What is the most important interaction to flag?

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Correct answer: D — Potential increased apixaban exposure and bleeding risk

Diltiazem can increase exposure to some DOACs and patient factors may heighten bleeding risk. Dose appropriateness and monitoring should be reviewed. In this scenario, the correct option is potential increased apixaban exposure and bleeding risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions