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Rifampicin enzyme induction — GPhC CRA MCQ

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HardInfections and AntimicrobialsRifampicin enzyme inductionGPhC CRA

A patient taking rifampicin asks for advice because their combined oral contraceptive has been less regular. They have no missed pills. What is the most important interaction to flag?

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Correct answer: A — Reduced contraceptive effectiveness from enzyme induction

Rifampicin is a potent enzyme inducer and can reduce hormonal contraceptive effectiveness. Specialist contraceptive advice is required. In this scenario, the correct option is reduced contraceptive effectiveness from enzyme induction. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; FSRH