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Linezolid and SSRI — GPhC CRA MCQ

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HardDrug InteractionsLinezolid and SSRIGPhC CRA

A patient taking fluoxetine is prescribed linezolid after microbiology advice. They ask whether to continue antidepressant tablets. What is the most important interaction to flag?

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Correct answer: D — Serotonin toxicity risk requiring specialist management

Linezolid has monoamine oxidase inhibitor activity and can precipitate serotonin syndrome with SSRIs. Management requires prescriber or specialist input. In this scenario, the correct option is serotonin toxicity risk requiring specialist management. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions