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Allopurinol renal dose — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentAllopurinol renal doseGPhC CRA

A patient with CKD is prescribed allopurinol 300 mg daily as a new start. They have never taken urate-lowering therapy. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Query starting dose and titration with renal function in mind

Allopurinol is generally started low and titrated, with renal function considered. A high starting dose in CKD increases adverse reaction concern. In this scenario, the correct option is query starting dose and titration with renal function in mind. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; NICE CKS