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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A patient taking sertraline asks for ibuprofen for period pain. They also has a history of gastritis. What is the most important interaction to flag?

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Correct answer: C — Increased gastrointestinal bleeding risk

SSRIs can increase bleeding tendency and NSAIDs add gastrointestinal bleeding risk. Safer analgesia or gastroprotection review may be needed. In this scenario, the correct option is increased gastrointestinal bleeding risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions