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NSAID warfarin interaction — GPhC CRA MCQ

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EasyMusculoskeletal TherapeuticsNSAID warfarin interactionGPhC CRA

A patient taking warfarin requests naproxen for shoulder pain. Their last INR was in range and they have no bleeding symptoms. What is the most important interaction to flag?

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Correct answer: B — Increased bleeding risk from NSAID plus anticoagulant

NSAIDs increase gastrointestinal and other bleeding risks with anticoagulants. Safer analgesia or prescriber review should be considered. In this scenario, the correct option is increased bleeding risk from NSAID plus anticoagulant. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions