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Azole and statin — GPhC CRA MCQ

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ModerateDrug InteractionsAzole and statinGPhC CRA

A patient taking simvastatin asks to buy oral fluconazole for recurrent thrush. They had muscle pain during a previous antifungal course. What is the most important interaction to flag?

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Correct answer: C — Increased statin concentration and myopathy risk

Azole antifungals can inhibit statin metabolism and raise myopathy risk. The pharmacist should avoid unsupervised supply and consider referral. In this scenario, the correct option is increased statin concentration and myopathy risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-58