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Tramadol and SSRI — GPhC CRA MCQ

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ModerateCNS TherapeuticsTramadol and SSRIGPhC CRA

A patient taking citalopram is prescribed tramadol for acute back pain. They have previously had dizziness with opioids. What is the most important interaction to flag?

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Correct answer: E — Increased serotonin syndrome and seizure risk

Tramadol has serotonergic activity and can lower seizure threshold. Combined use with an SSRI is clinically important and should be queried or closely managed. In this scenario, the correct option is increased serotonin syndrome and seizure risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions