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Sildenafil and GTN — GPhC CRA MCQ

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ModerateDrug InteractionsSildenafil and GTNGPhC CRA

A man using GTN spray for angina asks to buy sildenafil after seeing an online advert. What is the most important interaction to flag?

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Correct answer: CSevere hypotension from nitrate and PDE5 inhibitor combination

Nitrates and PDE5 inhibitors can cause profound hypotension when combined. This makes severe hypotension from nitrate and pde5 inhibitor combination the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions