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Valproate and lamotrigine — GPhC CRA MCQ

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ModerateDrug InteractionsValproate and lamotrigineGPhC CRA

A patient taking sodium valproate starts lamotrigine and develops a rash after rapid dose escalation. What is the most important interaction to flag?

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Correct answer: A — Valproate increases lamotrigine exposure and rash risk

Valproate inhibits lamotrigine metabolism, increasing exposure and serious rash risk. This makes valproate increases lamotrigine exposure and rash risk the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions