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Antacid and levothyroxine — GPhC CRA MCQ

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HardGastrointestinal TherapeuticsAntacid and levothyroxineGPhC CRA

A patient taking levothyroxine every morning buys an aluminium/magnesium antacid and plans to take both together. What is the most important interaction to flag?

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Correct answer: AReduced levothyroxine absorption

Antacids containing aluminium or magnesium can reduce levothyroxine absorption if taken together. This makes reduced levothyroxine absorption the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions