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Linezolid and sertraline — GPhC CRA MCQ

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ModerateDrug InteractionsLinezolid and sertralineGPhC CRA

A patient taking sertraline is discharged on linezolid for resistant infection without antidepressant review. What is the most important interaction to flag?

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Correct answer: C — Risk of serotonin syndrome

Linezolid can interact with serotonergic antidepressants because of monoamine oxidase inhibition. This makes risk of serotonin syndrome the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions