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Lamotrigine rash — GPhC CRA MCQ

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EasyCNS TherapeuticsLamotrigine rashGPhC CRA

A patient started lamotrigine 3 weeks ago and now has a widespread rash with fever and mouth ulcers. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EAdvise urgent medical assessment and withhold further doses pending review

Rash with systemic symptoms on lamotrigine may indicate a serious cutaneous adverse reaction. This makes advise urgent medical assessment and withhold further doses pending review the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF