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Clostridioides difficile suspicion — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardGastrointestinal TherapeuticsClostridioides difficile suspicionGPhC CRA

A 54 kg woman has taken hydroxychloroquine 300 mg daily for six years. She has no renal disease, tamoxifen use or previous retinal monitoring. Which action best reflects UK guidance?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Arrange annual retinal monitoring now and request review of the weight-adjusted daily dose

Explanation lettering: E = shown as B · B = shown as C · C = shown as D · D = shown as E

A delays monitoring beyond the standard five-year threshold. B is correct: after five years, standard-risk patients should enter annual retinal monitoring, and 300 mg in a 54 kg patient is about 5.6 mg/kg/day, above the ideal maximum, so the dose needs prescriber review. C is wrong because visual-acuity testing alone is not the recommended multimodal retinal screen. D is wrong because exceeding the dose threshold raises risk but does not prove toxicity or justify abrupt unsupervised cessation. E uses an obsolete cumulative-dose trigger.

Reference: Royal College of Ophthalmologists: hydroxychloroquine and chloroquine retinopathy monitoring guideline. https://www.rcophth.ac.uk/wp-content/uploads/2020/12/Hydroxychloroquine-and-Chloroquine-Retinopathy-Monitoring-Guideline.pdf