Sertraline and tramadol — GPhC CRA MCQ

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EasyCNS TherapeuticsSertraline and tramadolGPhC CRA

A patient taking sertraline is prescribed tramadol for back pain and has a past seizure history. What is the most important interaction to flag?

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Correct answer: A — Serotonin toxicity and seizure risk may increase

Tramadol has serotonergic activity and can lower seizure threshold, making this combination clinically concerning. This makes serotonin toxicity and seizure risk may increase the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions