Clopidogrel and omeprazole — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyCardiovascular TherapeuticsClopidogrel and omeprazoleGPhC CRA

A 72-year-old man taking clopidogrel after a TIA is newly prescribed omeprazole for dyspepsia. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Reduced antiplatelet effect of clopidogrel

Omeprazole can reduce clopidogrel activation through CYP2C19 inhibition. This makes reduced antiplatelet effect of clopidogrel the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions; NICE CKS