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Eplerenone and clarithromycin — GPhC CRA MCQ

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EasyDrug InteractionsEplerenone and clarithromycinGPhC CRA

A man taking eplerenone after MI is prescribed clarithromycin and his potassium was 5.0 mmol/L last month. What is the most important interaction to flag?

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Correct answer: E — Increased eplerenone exposure and hyperkalaemia risk

Clarithromycin can inhibit metabolism of eplerenone and increase hyperkalaemia risk. This makes increased eplerenone exposure and hyperkalaemia risk the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions