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Methotrexate weekly dosing — GPhC CRA MCQ

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EasyMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A new prescription for methotrexate 10 mg daily for rheumatoid arthritis conflicts with the consultant's verbal advice to take it on Mondays. What is the most appropriate action?

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Correct answer: E — Query the prescription urgently before supply

Methotrexate for rheumatoid arthritis is usually taken once weekly and daily dosing is a serious medication error risk. This makes query the prescription urgently before supply the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF; NPSA/MHRA safety guidance