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Methotrexate and trimethoprim — GPhC CRA MCQ

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ModerateDrug InteractionsMethotrexate and trimethoprimGPhC CRA

A woman taking weekly methotrexate is prescribed trimethoprim for UTI and her last FBC was borderline low. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Check full blood count and contact the prescriber before supply

Trimethoprim can increase antifolate toxicity with methotrexate, so blood count assessment and prescriber review are required. This makes check full blood count and contact the prescriber before supply the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions