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SGLT2 inhibitor sick day advice — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsSGLT2 inhibitor sick day adviceGPhC CRA

A patient taking dapagliflozin has fever, vomiting and reduced oral intake; glucose is 8 mmol/L but they feel very unwell. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Pause dapagliflozin and seek advice about ketone testing

SGLT2 inhibitors can be associated with ketoacidosis during acute illness, sometimes without marked hyperglycaemia. This makes pause dapagliflozin and seek advice about ketone testing the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: MHRA; BNF; NICE CKS