Linezolid and SSRI — GPhC CRA MCQ

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HardCNS TherapeuticsLinezolid and SSRIGPhC CRA

A discharge prescription includes linezolid for pneumonia in a patient taking citalopram 20 mg daily. What is the most important interaction to flag?

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Correct answer: D — Risk of serotonin syndrome

Linezolid has monoamine oxidase inhibitor activity and can interact with SSRIs. This makes risk of serotonin syndrome the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions