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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A patient taking fluoxetine asks to buy ibuprofen for shoulder pain and has previous gastritis. What is the most important interaction to flag?

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Correct answer: B — Increased risk of gastrointestinal bleeding

SSRIs can increase bleeding risk, and combining with NSAIDs increases GI bleeding risk further. This makes increased risk of gastrointestinal bleeding the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: BNF interactions