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Valproate safety alert — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyValproate safety alertGPhC CRA

A 17-year-old on valproate for migraine prevention requests a repeat with no specialist review letter or pregnancy prevention process. What is the most appropriate action?

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Correct answer: D — Do not make routine supply without urgent prescriber clarification

Valproate has major reproductive safety restrictions and migraine prophylaxis use in people who could become pregnant is highly restricted. This makes do not make routine supply without urgent prescriber clarification the single best answer in this scenario. The other options would either miss the key safety issue, delay appropriate review, or fail to meet the relevant clinical or professional requirement.

Reference: MHRA; BNF