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Pregabalin controlled drug status — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS TherapeuticsPregabalin controlled drug statusGPhC CRA

A patient established on clozapine 300 mg at night has missed three complete days because of gastroenteritis. They feel well again and ask whether to resume 300 mg tonight. Which instruction is correct?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Contact the clozapine team and restart at 12.5 mg once or twice on day one

Explanation lettering: D = shown as A · C = shown as B · B = shown as C · E = shown as D · A = shown as E

A is unsafe because more than two days without clozapine removes the tolerance that permits immediate return to the maintenance dose. B is correct: after an interval exceeding two days, the SmPC requires re-initiation at 12.5 mg once or twice on the first day, coordinated with the clozapine team and monitoring service. C still begins above the specified re-initiation dose. D invents an accelerated restart schedule that begins too high. E adds an unsupported seven-day delay and still proposes an unsafe full-dose restart; a blood count alone does not replace re-titration.

Reference: Clozaril 200 mg tablets SmPC. https://www.medicines.org.uk/emc/product/102057/smpc