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Home oxygen smoking risk — GPhC CRA MCQ

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HardRespiratory TherapeuticsHome oxygen smoking riskGPhC CRA

A patient taking sertraline requires intravenous methylthioninium chloride for clinically significant acquired methaemoglobinaemia. Which serious interaction must the treating team actively manage?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DMethylthioninium chloride can precipitate serotonin syndrome with sertraline

Explanation lettering: D = shown as A · C = shown as B · E = shown as C · A = shown as D · B = shown as E

A is correct: methylthioninium chloride is an MAO inhibitor, and serious or fatal serotonin syndrome has occurred with serotonergic medicines including SSRIs; urgent use requires specialist risk–benefit assessment, consideration of alternatives and close monitoring. B invents a folate mechanism. C describes neither drug’s relevant pharmacology. D reverses the concern, which is serotonergic toxicity rather than chelation. E is chemically false.

Reference: Proveblue methylthioninium chloride SmPC. https://www.medicines.org.uk/emc/product/6898/smpc