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Terbinafine liver toxicity — GPhC CRA MCQ

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HardInfectionsTerbinafine liver toxicityGPhC CRA

A 63-year-old woman is prescribed terbinafine tablets for fungal nail infection. She reports dark urine, pale stools and itching after three weeks of treatment. She has no abdominal pain. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Stop terbinafine and arrange urgent medical assessment for possible liver injury

Oral terbinafine can rarely cause hepatotoxicity. Dark urine, pale stools and pruritus are concerning symptoms and require urgent review and liver function assessment. Treatment should not simply be continued in the presence of possible liver injury.

Reference: BNF