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Lithium and NSAIDs — GPhC CRA MCQ

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ModerateDrug InteractionsLithium and NSAIDsGPhC CRA

A 70-year-old man takes lithium and asks to buy ibuprofen for hip pain. He has had diarrhoea for two days and feels thirsty. What is the most appropriate action?

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Correct answer: B — Advise against ibuprofen and refer because lithium toxicity risk is increased

NSAIDs can increase lithium levels, and dehydration from diarrhoea further increases toxicity risk. The patient's thirst and acute illness make this higher risk. He should avoid ibuprofen and seek clinical advice, with lithium level assessment if symptoms suggest toxicity.

Reference: BNF