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Lamotrigine and combined pill — GPhC CRA MCQ

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ModerateDrug InteractionsLamotrigine and combined pillGPhC CRA

A 34-year-old woman takes lamotrigine for epilepsy and starts a combined oral contraceptive pill. She asks why her neurologist wants to review seizure control. What is the most important interaction to flag?

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Correct answer: A — Combined hormonal contraception can reduce lamotrigine levels

Combined hormonal contraception can reduce lamotrigine concentrations and may worsen seizure control. Lamotrigine levels may also change during pill-free intervals. Specialist review is appropriate when starting or stopping hormonal contraception.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-49