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Clopidogrel PPI selection — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel PPI selectionGPhC CRA

A 69-year-old man takes clopidogrel after a coronary stent. He asks to buy esomeprazole because omeprazole helped his reflux previously. He has no alarm symptoms and takes no anticoagulant. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Suggest discussing a non-omeprazole PPI option such as lansoprazole with the prescriber

Omeprazole and esomeprazole are generally avoided with clopidogrel because they may reduce antiplatelet activation. If a PPI is indicated, another PPI may be preferred according to local guidance. The pharmacist should avoid suggesting changes to antiplatelet therapy without prescriber input.

Reference: BNF