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C difficile infection — GPhC CRA MCQ

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ModerateInfectionsC difficile infectionGPhC CRA

A 78-year-old man completed co-amoxiclav last week and now has watery diarrhoea, abdominal cramps and fever. He has been taking loperamide for two days without benefit. What is the most appropriate action?

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Correct answer: B — Refer urgently for possible Clostridioides difficile infection

Antibiotic-associated diarrhoea with fever in an older patient raises concern for Clostridioides difficile infection. Antimotility medicines may be inappropriate and medical assessment is needed. Hydration advice and infection-control precautions should also be discussed.

Reference: NICE CKS; BNF