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Methotrexate tablet strength — GPhC CRA MCQ

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HardDispensing and SupplyMethotrexate tablet strengthGPhC CRA

A prescription for methotrexate 10mg tablets is received for a patient who usually takes 2.5mg tablets. The dose is 20mg once weekly and the patient has previously confused tablet strengths. What is the legal classification/requirement?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Query the strength and consider dispensing 2.5mg tablets to reduce dosing error risk

Methotrexate 10mg tablets have been associated with serious dosing errors. Many safety recommendations favour using 2.5mg tablets where possible and avoiding mixed strengths. The pharmacist should query and counsel clearly on weekly dosing and toxicity symptoms.

Reference: BNF; MHRA safety advice