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Ciprofloxacin and tizanidine — GPhC CRA MCQ

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HardDrug InteractionsCiprofloxacin and tizanidineGPhC CRA

A 58-year-old man takes tizanidine for spasticity and is prescribed ciprofloxacin for UTI. He asks whether to start both today. What is the most important interaction to flag?

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Correct answer: B — Ciprofloxacin can greatly increase tizanidine exposure and hypotension risk

Ciprofloxacin can markedly increase tizanidine concentrations and cause hypotension, sedation and other toxicity. The combination is generally avoided. The prescriber should select an alternative antibiotic or spasticity plan.

Reference: BNF