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Antipsychotic constipation — GPhC CRA MCQ

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ModerateCNS TherapeuticsAntipsychotic constipationGPhC CRA

A 48-year-old man collecting quetiapine reports new severe constipation, abdominal pain and vomiting. He also takes co-codamol for back pain. He has not opened his bowels for six days. What is the most appropriate action?

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Correct answer: C — Refer urgently because antipsychotics can contribute to severe gastrointestinal hypomotility

Antipsychotics with anticholinergic effects, and opioids, can contribute to severe constipation and gastrointestinal hypomotility. Abdominal pain, vomiting and no bowel movement for six days are red flags for obstruction or ileus. Urgent medical assessment is needed.

Reference: BNF; MHRA safety advice