A 62-year-old woman develops symmetrical ankle oedema after amlodipine is increased from 5 mg to 10 mg daily. There is no breathlessness, raised JVP

Question

A 62-year-old woman develops symmetrical ankle oedema after amlodipine is increased from 5 mg to 10 mg daily. There is no breathlessness, raised JVP or weight gain. Which mechanism best explains why adding furosemide is unlikely to solve the problem?

Accepted Answer

Preferential arteriolar dilation raises capillary hydrostatic pressure without sodium retention

Answer

Peripheral oedema results from direct nephrotoxicity and reduced glomerular filtration

Answer

Selective venoconstriction causes renal sodium retention through aldosterone release

Answer

Amlodipine blocks the natriuretic response to loop diuretics in the thick ascending limb

Answer

Reduced lymphatic protein synthesis produces a true intravascular volume excess

Amlodipine ankle oedema — GPhC CRA MCQ

A 62-year-old woman develops symmetrical ankle oedema after amlodipine is increased from 5 mg to 10 mg daily. There is no breathlessness, raised JVP or weight gain. Which mechanism best explains why adding furosemide is unlikely to solve the problem?