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DPP-4 inhibitor arthralgia — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsDPP-4 inhibitor arthralgiaGPhC CRA

A 62-year-old man prescribed alogliptin asks whether joint pain that started after initiation could be related. The pain is severe and affects his hands and knees. He takes metformin and atorvastatin. What monitoring is required?

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Correct answer: D — Refer to the prescriber to assess possible DPP-4 inhibitor-associated arthralgia

Severe joint pain has been reported with DPP-4 inhibitors. Although other causes are possible, the timing after initiation makes medicine-related arthralgia worth reviewing. The prescriber can assess whether withdrawal or an alternative diabetes therapy is appropriate.

Reference: BNF; MHRA Drug Safety Update