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Citalopram and fluconazole — GPhC CRA MCQ

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HardDrug InteractionsCitalopram and fluconazoleGPhC CRA

A 65-year-old woman takes citalopram 20mg daily and is prescribed fluconazole 150mg single dose for candidiasis. She has a history of QT prolongation. What is the most important interaction to flag?

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Correct answer: D — Fluconazole may increase QT-related risk with citalopram

Both citalopram and fluconazole can contribute to QT prolongation risk, and fluconazole can affect metabolism of some medicines. A history of QT prolongation increases concern even with short courses. The pharmacist should check the clinical context and consider prescriber advice.

Reference: BNF