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Warfarin and amiodarone — GPhC CRA MCQ

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ModerateDrug InteractionsWarfarin and amiodaroneGPhC CRA

A 68-year-old man taking warfarin is started on amiodarone for atrial fibrillation. His anticoagulant clinic is not aware yet. He asks whether his INR checks need changing. What monitoring is required?

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Correct answer: C — Arrange closer INR monitoring because amiodarone can increase warfarin effect

Amiodarone can increase the anticoagulant effect of warfarin and raise INR, with effects that may develop over time. The anticoagulant clinic or prescriber should be informed so INR monitoring and dosing can be adjusted. The patient should be counselled about bleeding symptoms.

Reference: BNF