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Nitrofurantoin pulmonary toxicity — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and SafetyNitrofurantoin pulmonary toxicityGPhC CRA

A 61-year-old woman takes long-term nitrofurantoin prophylaxis for recurrent UTI. She reports new persistent cough and breathlessness over several weeks. She has no fever. What is the most appropriate action?

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Correct answer: A — Refer for assessment of possible nitrofurantoin pulmonary toxicity

Nitrofurantoin can cause pulmonary toxicity, including chronic reactions with cough and breathlessness. Long-term prophylaxis increases the relevance of this adverse effect. The patient should be referred for clinical review and the need for ongoing prophylaxis reassessed.

Reference: BNF; MHRA safety advice