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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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ModerateRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A 15-year-old boy recently started montelukast for asthma. His parent reports new nightmares, low mood and agitation since treatment began. There have been no other medicine changes. What is the most appropriate alternative?

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Correct answer: C — Advise prompt prescriber review because of possible neuropsychiatric adverse effects

Montelukast has been associated with neuropsychiatric reactions, including sleep disturbance, mood changes and agitation. New symptoms after initiation require prompt clinical review and risk-benefit reassessment. The family should be advised to seek urgent help if there are thoughts of self-harm or severe behavioural changes.

Reference: BNF; MHRA Drug Safety Update