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Long-term PPI safety — GPhC CRA MCQ

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ModerateGastro-intestinal TherapeuticsLong-term PPI safetyGPhC CRA

A 75-year-old man taking lansoprazole long term for reflux asks whether he still needs it. He has had two chest infections and a recent episode of diarrhoea after antibiotics. He has no current reflux symptoms. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Review the ongoing indication and consider step-down with the prescriber

Long-term PPI therapy should be reviewed to ensure there remains a clear indication. PPIs are associated with potential risks, including enteric infection, although causality varies by outcome. Step-down, on-demand use or stopping may be appropriate depending on history and risk factors.

Reference: BNF; NICE CKS