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Allopurinol hypersensitivity — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyAllopurinol hypersensitivityGPhC CRA

A 52-year-old man taking allopurinol started treatment two weeks ago and now has a widespread rash, fever and facial swelling. He has CKD stage 3. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Stop allopurinol and arrange urgent medical assessment

Allopurinol can rarely cause severe hypersensitivity reactions, with risk increased in renal impairment and early treatment. Rash with fever and facial swelling requires urgent assessment. The medicine should be stopped pending medical review.

Reference: BNF; NICE CKS