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Statin muscle toxicity — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsStatin muscle toxicityGPhC CRA

A 63-year-old man takes atorvastatin 40mg daily. He reports new unexplained muscle pain and dark urine after starting clarithromycin for pneumonia two days ago. He feels unwell and has reduced urine output. What is the most appropriate action?

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Correct answer: C — Refer urgently for assessment of possible statin-associated rhabdomyolysis

Macrolides can increase statin exposure and muscle toxicity risk, and dark urine with systemic symptoms is concerning for rhabdomyolysis. The patient needs urgent assessment, including creatine kinase and renal function. Continuing the interacting combination without review could cause harm.

Reference: BNF